Bone vs vascular mineralization
ECTS eCampus. Kempf H. 07/05/22; 369950
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Under physiological circumstances, mineralization of the extra-cellular matrix occurs exclusively in the skeleton tissues, i.e. bones and teeth. However, in some pathological conditions, ectopic calcification can also take place in tissues normally immune to calcification, such as arteries.
Pathological mineralization of the vascular wall, called vascular calcification, is associated with aging as well as pathologies such as atherosclerosis, diabetes or renal insufficiency or various rare diseases. Although vascular calcification, which is an important indicator of cardiovascular morbidity and mortality, has long been thought to be a degenerative passive process, intense research over the last two decades has now clearly demonstrated that vascular calcification is an active process, which, to some extent, recapitulates the processes involved in skeletal mineralization.
This course will provide a general overview of the commonalities and differences between bone and vascular mineralization.
Pathological mineralization of the vascular wall, called vascular calcification, is associated with aging as well as pathologies such as atherosclerosis, diabetes or renal insufficiency or various rare diseases. Although vascular calcification, which is an important indicator of cardiovascular morbidity and mortality, has long been thought to be a degenerative passive process, intense research over the last two decades has now clearly demonstrated that vascular calcification is an active process, which, to some extent, recapitulates the processes involved in skeletal mineralization.
This course will provide a general overview of the commonalities and differences between bone and vascular mineralization.
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