Osteoimmunology and osteoclasts in chronic inflammation
ECTS eCampus. Blin C. 07/05/22; 369949
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Osteoimmunology is the field of research that combines immunology and bone biology. Indeed, chronic inflammatory diseases are very frequently associated with bone destruction. This is mainly due to the overproduction of inflammatory mediators that increase differentiation of the bone-resorbing osteoclasts. However, interactions between immune cells and bone cells are more complex, in particular regarding osteoclasts because they belong to the monocytic lineage and, as such, they also have an innate immune function and directly participate in regulating immune responses toward immune tolerance or inflammation. Moreover, these divergent effects are related to the existence of functionally and transcriptionally distinct osteoclast subpopulations. Therefore, bone destruction would not only rely on an increased number of osteoclasts but also on differences in osteoclast subsets, which opens very novel perspectives for fighting against inflammatory bone destruction. Focusing on a few examples, we will discuss these reciprocal interactions between immune cells and osteoclasts and the importance of osteoclast diversity in osteoimmunology.
Recommended reading:
1- Madel et al. Immune Function and Diversity of Osteoclasts in Normal and Pathological Conditions. Front Immunol. 2019 Jun 19;10:1408. doi: 10.3389/fimmu.2019.01408. eCollection 2019.
2- Andreev et al. Rheumatoid arthritis and osteoimmunology: The adverse impact of a deregulated immune system on bone metabolism. Bone 2022 DOI: 10.1016/j.bone.2022.116468
1- Madel et al. Immune Function and Diversity of Osteoclasts in Normal and Pathological Conditions. Front Immunol. 2019 Jun 19;10:1408. doi: 10.3389/fimmu.2019.01408. eCollection 2019.
2- Andreev et al. Rheumatoid arthritis and osteoimmunology: The adverse impact of a deregulated immune system on bone metabolism. Bone 2022 DOI: 10.1016/j.bone.2022.116468
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