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Topic: Osteoporosis: treatment
Cardoso, Rui(1)*;Genrinho, Inês(2);Silva, Susana(2);Mazeda, Carolina(2);Vilas Boas, Bernardo(2);Brenha, José(1);Barcelos, Anabela(2);
(1)Centro Hospitalar Baixo Vouga, Orthopedic and Traumatology Department, Aveiro, Portugal;(2)Centro Hospitalar Baixo Vouga, Rheumatology Department, Aveiro, Portugal;
Abstract Text
BACKGROUND: Bisphosphonates (BP) are highly effective in treating osteoporosis post-menopausal women and reducing fractures. However, atypical femoral fractures (AFFs) emerged as a rare event associated with increased duration of BP exposure.
PURPOSE: To evaluate clinical and metabolic characteristics in patients with AFFs, in order to determine risk factors associated.
METHODS: We retrospectively reviewed the medical records and radiographs of twenty-five caucasian women, 50 years old of age or older, admitted to the emergency of Orthopedic Department for surgical repair between 2017 and 2021. All the women were under BPs therapy prior to the fracture events and suffered a femoral shaft fracture. Of those, eleven were classified as AFF according to the American Society for Bone and Mineral Research criteria and fourteen were classified as typical femoral fractures (TFF). Duration of BPs intake, metabolic factors, comorbid conditions and concomitant therapies were compared.
RESULTS: AFF patients received BPs therapy for a higher period than TFF (p < 0.05). Early menopausal age and hypothyroidism with levotiroxin intake were more prevalent in AFF patients (p < 0.05). At the time of the fracture a higher prevalence of hypocalcemia and reduced prevalence of elevated PTH levels were observed in AFF patients, although not statistically significant. Other risk factors as age, race, body mass index, pulmonary or collagen diseases, glucocorticoid or pump proton inhibitors use or D vitamin levels did not differ significantly in both groups.
CONCLUSION: Our data indicate that patients treated with BP with early menopausal age and with hypothyroidism with levotiroxin intake are at higher AFF risk. In these patients we should monitor or be alert for signs of incomplete AFFs to consider prophylactic surgery.
Topic: Osteoporosis: treatment
Cardoso, Rui(1)*;Genrinho, Inês(2);Silva, Susana(2);Mazeda, Carolina(2);Vilas Boas, Bernardo(2);Brenha, José(1);Barcelos, Anabela(2);
(1)Centro Hospitalar Baixo Vouga, Orthopedic and Traumatology Department, Aveiro, Portugal;(2)Centro Hospitalar Baixo Vouga, Rheumatology Department, Aveiro, Portugal;
Abstract Text
BACKGROUND: Bisphosphonates (BP) are highly effective in treating osteoporosis post-menopausal women and reducing fractures. However, atypical femoral fractures (AFFs) emerged as a rare event associated with increased duration of BP exposure.
PURPOSE: To evaluate clinical and metabolic characteristics in patients with AFFs, in order to determine risk factors associated.
METHODS: We retrospectively reviewed the medical records and radiographs of twenty-five caucasian women, 50 years old of age or older, admitted to the emergency of Orthopedic Department for surgical repair between 2017 and 2021. All the women were under BPs therapy prior to the fracture events and suffered a femoral shaft fracture. Of those, eleven were classified as AFF according to the American Society for Bone and Mineral Research criteria and fourteen were classified as typical femoral fractures (TFF). Duration of BPs intake, metabolic factors, comorbid conditions and concomitant therapies were compared.
RESULTS: AFF patients received BPs therapy for a higher period than TFF (p < 0.05). Early menopausal age and hypothyroidism with levotiroxin intake were more prevalent in AFF patients (p < 0.05). At the time of the fracture a higher prevalence of hypocalcemia and reduced prevalence of elevated PTH levels were observed in AFF patients, although not statistically significant. Other risk factors as age, race, body mass index, pulmonary or collagen diseases, glucocorticoid or pump proton inhibitors use or D vitamin levels did not differ significantly in both groups.
CONCLUSION: Our data indicate that patients treated with BP with early menopausal age and with hypothyroidism with levotiroxin intake are at higher AFF risk. In these patients we should monitor or be alert for signs of incomplete AFFs to consider prophylactic surgery.
Topic: Osteoporosis: treatment
Cardoso, Rui(1)*;Genrinho, Inês(2);Silva, Susana(2);Mazeda, Carolina(2);Vilas Boas, Bernardo(2);Brenha, José(1);Barcelos, Anabela(2);
(1)Centro Hospitalar Baixo Vouga, Orthopedic and Traumatology Department, Aveiro, Portugal;(2)Centro Hospitalar Baixo Vouga, Rheumatology Department, Aveiro, Portugal;
Abstract Text
BACKGROUND: Bisphosphonates (BP) are highly effective in treating osteoporosis post-menopausal women and reducing fractures. However, atypical femoral fractures (AFFs) emerged as a rare event associated with increased duration of BP exposure.
PURPOSE: To evaluate clinical and metabolic characteristics in patients with AFFs, in order to determine risk factors associated.
METHODS: We retrospectively reviewed the medical records and radiographs of twenty-five caucasian women, 50 years old of age or older, admitted to the emergency of Orthopedic Department for surgical repair between 2017 and 2021. All the women were under BPs therapy prior to the fracture events and suffered a femoral shaft fracture. Of those, eleven were classified as AFF according to the American Society for Bone and Mineral Research criteria and fourteen were classified as typical femoral fractures (TFF). Duration of BPs intake, metabolic factors, comorbid conditions and concomitant therapies were compared.
RESULTS: AFF patients received BPs therapy for a higher period than TFF (p < 0.05). Early menopausal age and hypothyroidism with levotiroxin intake were more prevalent in AFF patients (p < 0.05). At the time of the fracture a higher prevalence of hypocalcemia and reduced prevalence of elevated PTH levels were observed in AFF patients, although not statistically significant. Other risk factors as age, race, body mass index, pulmonary or collagen diseases, glucocorticoid or pump proton inhibitors use or D vitamin levels did not differ significantly in both groups.
CONCLUSION: Our data indicate that patients treated with BP with early menopausal age and with hypothyroidism with levotiroxin intake are at higher AFF risk. In these patients we should monitor or be alert for signs of incomplete AFFs to consider prophylactic surgery.
Topic: Osteoporosis: treatment
Cardoso, Rui(1)*;Genrinho, Inês(2);Silva, Susana(2);Mazeda, Carolina(2);Vilas Boas, Bernardo(2);Brenha, José(1);Barcelos, Anabela(2);
(1)Centro Hospitalar Baixo Vouga, Orthopedic and Traumatology Department, Aveiro, Portugal;(2)Centro Hospitalar Baixo Vouga, Rheumatology Department, Aveiro, Portugal;
Abstract Text
BACKGROUND: Bisphosphonates (BP) are highly effective in treating osteoporosis post-menopausal women and reducing fractures. However, atypical femoral fractures (AFFs) emerged as a rare event associated with increased duration of BP exposure.
PURPOSE: To evaluate clinical and metabolic characteristics in patients with AFFs, in order to determine risk factors associated.
METHODS: We retrospectively reviewed the medical records and radiographs of twenty-five caucasian women, 50 years old of age or older, admitted to the emergency of Orthopedic Department for surgical repair between 2017 and 2021. All the women were under BPs therapy prior to the fracture events and suffered a femoral shaft fracture. Of those, eleven were classified as AFF according to the American Society for Bone and Mineral Research criteria and fourteen were classified as typical femoral fractures (TFF). Duration of BPs intake, metabolic factors, comorbid conditions and concomitant therapies were compared.
RESULTS: AFF patients received BPs therapy for a higher period than TFF (p < 0.05). Early menopausal age and hypothyroidism with levotiroxin intake were more prevalent in AFF patients (p < 0.05). At the time of the fracture a higher prevalence of hypocalcemia and reduced prevalence of elevated PTH levels were observed in AFF patients, although not statistically significant. Other risk factors as age, race, body mass index, pulmonary or collagen diseases, glucocorticoid or pump proton inhibitors use or D vitamin levels did not differ significantly in both groups.
CONCLUSION: Our data indicate that patients treated with BP with early menopausal age and with hypothyroidism with levotiroxin intake are at higher AFF risk. In these patients we should monitor or be alert for signs of incomplete AFFs to consider prophylactic surgery.